资源类型

期刊论文 964

年份

2024 1

2023 64

2022 94

2021 75

2020 69

2019 56

2018 44

2017 72

2016 43

2015 50

2014 42

2013 35

2012 34

2011 32

2010 29

2009 37

2008 36

2007 51

2006 25

2005 14

展开 ︾

关键词

仿真 8

质量控制 6

控制 5

智能控制 4

中药 3

主动控制 3

产业发展 3

模糊控制 3

神经网络 3

自适应控制 3

解耦控制 3

风险控制 3

三峡升船机 2

三峡工程 2

不确定性 2

京津冀 2

人工智能 2

优化 2

优化设计 2

展开 ︾

检索范围：

排序： 展示方式：

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

《医学前沿（英文）》 2020年 第14卷 第2期   页码 117-125 doi: 10.1007/s11684-020-0773-x

摘要： Since the outbreak of the COVID-19 pandemic in early December 2019, 81 174 confirmed cases and 3242 deaths have been reported in China as of March 19, 2020. The Chinese people and government have contributed huge efforts to combat this disease, resulting in significant improvement of the situation, with 58 new cases (34 were imported cases) and 11 new deaths reported on March 19, 2020. However, as of March 19, 2020, the COVID-19 pandemic continues to develop in 167 countries/territories outside of China, and 128 665 confirmed cases and 5536 deaths have been reported, with 16 498 new cases and 817 new deaths occurring in last 24 hours. Therefore, the world should work together to fight against this pandemic. Here, we review the recent advances in COVID-19, including the insights in the virus, the responses of the host cells, the cytokine release syndrome, and the therapeutic approaches to inhibit the virus and alleviate the cytokine storm. By sharing knowledge and deepening our understanding of the virus and the disease pathogenesis, we believe that the community can efficiently develop effective vaccines and drugs, and the mankind will eventually win this battle against this pandemic.

关键词： COVID-19     SARS-CoV-2     pathogenesis     evidence-based medicine     control and therapeutic strategies    

HTML PDF 收藏

Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

《医学前沿（英文）》 2010年 第4卷 第1期   页码 36-42 doi: 10.1007/s11684-010-0020-y

摘要： Vulnerable atherosclerotic plaque rupture leading to thrombosis is the major cause of acute coronary syndrome (ACS). Studies on the pathophysiologic mechanism of both ACS and plaque stabilizing treatment are driving the development of animal models of vulnerable plaque. In our laboratory, we established animal models of plaque rupture and thrombosis in rabbits and mice that are similar to human plaque rupture. Potential mechanisms involved in plaque vulnerability were studied from the inflammation-immunity, proliferation-apoptosis, oxidative stress and biomechanics aspects. Imaging markers and biomarkers were used to detect vulnerable plaques, including high frequency duplex ultrasound, intravascular ultrasound (IVUS), intravascular ultrasound elastography, magnetic resonance imaging (MRI) and inflammatory markers. Effective gene and drug strategies to treat vulnerable plaques were explored.

关键词： vulnerable plaque     animal models     mechani-sm     detection     treatment    

HTML PDF 收藏

WHEAT STRIPE RUST AND INTEGRATION OF SUSTAINABLE CONTROL STRATEGIES IN CHINA

《农业科学与工程前沿（英文）》 2022年 第9卷 第1期   页码 37-51 doi: 10.15302/J-FASE-2021405

摘要：

Stripe (yellow) rust caused by Puccinia striiformis f. sp. tritici occurs in almost all wheat-producing regions of the world. Severe countrywide epidemics in China have caused substantial yield losses. Growing resistant cultivars is the best strategy to control this disease but the pathogen can overcome resistance in wheat cultivars. The high variation in the virulence of the pathogen combined with the large areas of susceptible wheat cultivars enables the pathogen population to increase rapidly and disperse over long distances under favorable environmental conditions, resulting in severe pandemics within cropping seasons. Current stripe rust control measures are based on many years of research including the underlying epidemiology regarding year-to-year survival of the pathogen, pathways of pathogen dispersal within seasons and years, the role of P. striiformis sexual hybridization, the use of resistance sources in breeding programs, and year-round surveillance of national wheat crops that are present in different parts of the country throughout the year. All these strategies depend on accurate prediction of epidemics, more precise use of fungicides to meet national requirements and better deployment of resistance genes. New ideas with potential application in sustainable protection of stripe rust include negative regulatory gene editing, resistance gene overexpression and biological control based on microbiomes.

 

关键词： sustainable disease control / integrated control Puccinia striiformis / Triticum aestivum    

HTML PDF 收藏

HEMIPTERAN-TRANSMITTED PLANT VIRUSES: RESEARCH PROGRESS AND CONTROL STRATEGIES

《农业科学与工程前沿（英文）》 2022年 第9卷 第1期   页码 98-109 doi: 10.15302/J-FASE-2021389

摘要：

About 80% of plant viruses are transmitted by specific insect vectors, especially hemipterans with piercing-sucking mouthparts. Many virus-transmitting insects are also important crop pests that cause considerable losses in crop production. This review summarizes the latest research findings on the interactions between plant viruses and insect vectors and analyzes the key factors affecting insect transmission of plant viruses from the perspectives of insect immunity, insect feeding, and insect symbiotic microorganisms. Additionally, by referring to the latest applications for blocking the transmission of animal viruses, potential control strategies to prevent the transmission of insect-vectored plant viruses using RNAi technology, gene editing technology, and CRISPR/Cas9+ gene-driven technology are discussed.

 

关键词： control strategies / feeding / immunity / insect vector / microorganism / plant virus    

HTML PDF 收藏

A review on the forward osmosis applications and fouling control strategies for wastewater treatment

《化学科学与工程前沿（英文）》 2022年 第16卷 第5期   页码 661-680 doi: 10.1007/s11705-021-2084-4

摘要： During the last decades, the utilization of osmotic pressure-driven forward osmosis technology for wastewater treatment has drawn great interest, due to its high separation efficiency, low membrane fouling propensity, high water recovery and relatively low energy consumption. This review paper summarizes the implementation of forward osmosis technology for various wastewater treatment including municipal sewage, landfill leachate, oil/gas exploitation wastewater, textile wastewater, mine wastewater, and radioactive wastewater. However, membrane fouling is still a critical issue, which affects water flux stability, membrane life and operating cost. Different membrane fouling types and corresponding fouling mechanisms, including organic fouling, inorganic fouling, biofouling and combined fouling are therefore further discussed. The fouling control strategies including feed pre-treatment, operation condition optimization, membrane selection and modification, membrane cleaning and tailoring the chemistry of draw solution are also reviewed comprehensively. At the end of paper, some recommendations are proposed.

关键词： forward osmosis     wastewater treatment     membrane fouling     fouling control    

HTML PDF 收藏

Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development

Long-de Wang

《工程管理前沿（英文）》 2015年 第2卷 第1期   页码 2-12 doi: 10.15302/J-FEM-2015002

摘要： Chronic non-communicable diseases have become a major threat to humanity. International studies have shown that of 57 million deaths worldwide in 2008, 36 million (63%) were caused by chronic non-communicable diseases; of these, 29 million (80%) occurred in low and middle income countries. The WHO predicts that if the current trend continues, the annual number of deaths due to chronic non-communicable diseases will increase to 55 million by 2030. Due to acceleration of industrialization and urbanization, along with population aging and rapid changes of people’s lifestyle, the morbidity and mortality from chronic diseases are rapidly increasing in China. Therefore, dealing with the prevalence of chronic non-communicable diseases has become one of the current major health issues for China to address. On the basis of summarizing the status of major chronic diseases in China, analyzing the key issues and key factors in chronic disease prevention and control, and reviewing and summarizing the experience from the previous projects, this paper proposes the following recommendations as strategies for chronic disease prevention and control and development of relevant system, which China should adopt. All relevant government departments should formulate corresponding policies; establish a coordinated and efficient work system with rational structure and clear division of tasks and responsibilities within the system. Implementation and development of “integrated medicine” in system is necessary. Work norms and requirements will then improve the performance and efficiency in chronic disease prevention and control in China.

关键词： chronic disease prevention and control     strategy and system construction    

HTML PDF 收藏

Control strategies for disinfection byproducts by ion exchange resin, nanofiltration and their sequential

《环境科学与工程前沿（英文）》 2023年 第17卷 第10期 doi: 10.1007/s11783-023-1725-x

摘要：

● Effects of AER adsorption and NF on DBP precursors, DBPs, and TOX were examined.

关键词： Disinfection byproducts     Control     Anion exchange resin     Nanofiltration     Cytotoxicity    

HTML PDF 收藏

Design and evaluation of control strategies in urban drainage systems in Kunming city

Xin Dong, Senchen Huang, Siyu Zeng

《环境科学与工程前沿（英文）》 2017年 第11卷 第4期 doi: 10.1007/s11783-017-0968-9

摘要： Real time control (RTC) of urban drainage systems (UDSs) is an important measure to reduce combined sewer overflow (CSO) and urban flooding, helping achieve the aims of ‘Sponge City’. Application of RTC requires three main steps: strategy design, simulation-based evaluation and field test. But many of published RTC studies are system-specific, lacking discussions on how to design a strategy step by step. In addition, the existing studies are prone to use hydrologic model to evaluated strategies, but a more precise and dynamic insight into strategy performance is needed. To fill these knowledge gaps, based on a case UDS in Kunming city, a study on RTC strategy design and simulation-based evaluation is performed. Two off-line volume-based RTC strategy design principles, and , are emphasized. Following these principles, a detailed design procedure is shown for the case UDS resulting in three RTC strategies: static, constant and equal filling. The proposed strategies are evaluated based on a hydrodynamic model- Storm Water Management Model (SWMM) - under four typical rainfall events characterized by different return periods (1-year or 0.5 year) and different spatial distributions (uniform or uneven). The equal filling strategy outperforms other two strategies and it can achieve 10% more CSO reduction and 5% more flooding reduction relative to the no-tank case.

关键词： Urban drainage system     Real time control     Static strategy     Constant strategy     Equal filling strategy    

HTML PDF 收藏

SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

《医学前沿（英文）》 2022年 第16卷 第2期   页码 185-195 doi: 10.1007/s11684-021-0913-y

摘要： The record speed at which Chinese scientists identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and shared its genomic sequence with the world, has greatly facilitated the development of coronavirus disease (COVID-19) diagnostics, drugs, and vaccines. It is unprecedented in pandemic control history to develop a dozen successful vaccines in the first year and to immunize over half of the global population in the second year, due to the efforts of the scientific community, biopharmaceutical industry, and regulatory agencies worldwide. The challenges are both great and multidimensional due to the rapid emergence of virus variants and waning of vaccine immunity. Vaccination strategies need to adapt to these challenges to keep population immunity above the herd immunity threshold, by increasing vaccine coverage, especially for older adults and young people, and providing timely booster doses with homologous or heterologous vaccine boosts. Further research should be undertaken to develop more effective vaccines against SARS-CoV-2 variants and to understand the best prime-boost vaccine combinations and immunization strategies to provide sufficient and sustainable immune protection against COVID-19.

关键词： COVID-19     pandemics     SARS-CoV-2     vaccination    

HTML PDF 收藏

Integrated control strategies for railway vehicles with independently-driven wheel motors

FENG Jinzhi, LI Jun, Goodall R. M.

《机械工程前沿（英文）》 2008年 第3卷 第3期   页码 239-250 doi: 10.1007/s11465-008-0053-y

摘要： This paper studies the development of integrated control strategies for railway vehicles with independently-driven wheel motors. First, a non-linear vehicle dynamic model and motor drive strategy are presented, which are followed by an investigation of the integrated control of stabilization, steering, and traction for the vehicle. Meanwhile a reformulated Kalman filter is developed and applied to estimate the required feedback by the control system. Finally, the effectiveness and practicality of the proposed integrated controller are examined and assessed by real-time simulation based on host-target computer technology provided by Matlab/Simulink.

关键词： development     independently-driven     non-linear     stabilization     reformulated    

HTML PDF 收藏

Impact of selection of DC base values and DC link control strategies on sequential AC-DC power-flow convergence

Shagufta KHAN,Suman BHOWMICK

《能源前沿（英文）》 2015年 第9卷 第4期   页码 399-412 doi: 10.1007/s11708-015-0374-6

摘要： This paper demonstrates the convergence of the integrated AC-DC power-flow algorithm as affected by the selection of different base values for the DC quantities and adoption of different control strategies for the DC link. For power-flow modeling of integrated AC-DC systems, the base values of the various DC quantities can be defined in several ways, giving rise to different sets of per-unit system equations. It is observed that different per-unit system models affect the convergence of the power-flow algorithm differently. In a similar manner, the control strategy adopted for the DC link also affects the power-flow convergence. The sequential method is used to solve the DC variables in the Newton Raphson (NR) power flow model, where AC and DC systems are solved separately and are coupled by injecting an equivalent amount of real and reactive power at the terminal AC buses. Now, for a majority of the possible control strategies, the equivalent real and reactive power injections at the concerned buses can be computed a-priori and are independent of the NR iterative loop. However, for a few of the control strategies, the equivalent reactive power injections cannot be computed a-priori and need to be computed in every NR iteration. This affects the performance of the iterative process. Two different per-unit system models and six typical control strategies are taken into consideration. This is validated by numerous case studies conducted on the IEEE 118-bus and 300-bus test systems.

关键词： AC-DC power-flow     Newton-Raphson method     high voltage direct current (HVDC) control strategy    

HTML PDF 收藏

Assessment of vaccination strategies against highly pathogenic avian influenza in China

Honglei SUN,Jinhua LIU

《农业科学与工程前沿（英文）》 2014年 第1卷 第4期   页码 277-281 doi: 10.15302/J-FASE-2014036

摘要： Vaccination for highly pathogenic avian influenza (HPAI) has been implemented in China for a decade, however, the virus is still present in poultry. A series of recombinant vaccines, Re-1 to Re-7, have been developed and used, and Re-8 will also be used in clinical settings to prevent the prevailing flu strains. The question remains, when can China eradicate the disease? Here, we review the epidemiology of H5 HPAI along with the development, usage and problems of vaccines. Further suggestions for controlling the disease in China are provided.

关键词： highly pathogenic avian influenza     vaccine     vaccination     control    

HTML PDF 收藏

High pressure air spray assistant power supply control strategies and their effects on diesel engine

HAN Yongqiang, LIU Zhongchang, WANG Zhongshu, ZHU Ruoqun

《能源前沿（英文）》 2007年 第1卷 第3期   页码 295-299 doi: 10.1007/s11708-007-0042-6

摘要： In order to reduce smoke from direct-injection (DI) turbo-charged and after-cooled (TCA) diesel engines under transient operations, the real-time controlling and measuring system of a high pressure air spray assistant power supply (HPAS) was developed. Effects of HPAS on a DI TCA diesel engine under constant engine speed and increased torque (CSIT) transient operations were studied by using different control strategies. Pre-spray (PS) strategy, which means supplying highly pressurized air into the exhaust manifold two seconds before the accelerating-graph begins to rise and stopping spraying air when the accelerating-graph stops rising. Two other strategies—full-time-spray (FTS) and middle-time-spray (MTS)—were used to fully exploit HPAS potential. With the FTS and MTS strategies, the HPAS system can remarkably decrease smoke from DI TCA diesel engines under transient operations.

关键词： different     after-cooled     real-time controlling     CSIT     supply    

HTML PDF 收藏

interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies

《医学前沿（英文）》   页码 805-822 doi: 10.1007/s11684-023-1025-7

摘要： Immunotherapies based on immune checkpoint blockade (ICB) have significantly improved patient outcomes and offered new approaches to cancer therapy over the past decade. To date, immune checkpoint inhibitors (ICIs) of CTLA-4 and PD-1/PD-L1 represent the main class of immunotherapy. Blockade of CTLA-4 and PD-1/PD-L1 has shown remarkable efficacy in several specific types of cancers, however, a large subset of refractory patients presents poor responsiveness to ICB therapy; and the underlying mechanism remains elusive. Recently, numerous studies have revealed that metabolic reprogramming of tumor cells restrains immune responses by remodeling the tumor microenvironment (TME) with various products of metabolism, and combination therapies involving metabolic inhibitors and ICIs provide new approaches to cancer therapy. Nevertheless, a systematic summary is lacking regarding the manner by which different targetable metabolic pathways regulate immune checkpoints to overcome ICI resistance. Here, we demonstrate the generalized mechanism of targeting cancer metabolism at three crucial immune checkpoints (CTLA-4, PD-1, and PD-L1) to influence ICB therapy and propose potential combined immunotherapeutic strategies co-targeting tumor metabolic pathways and immune checkpoints.

关键词： CTLA-4     PD-1     PD-L1     immune checkpoint blockade (ICB)     metabolic reprogramming     combined tumor therapeutic strategies    

HTML PDF 收藏

南方农产品产地主要环境问题成因与防治策略

黄彩红, 席北斗, 唐朱睿, 袁文超

《中国工程科学》 2018年 第20卷 第5期   页码 52-56 doi: 10.15302/J-SSCAE-2018.05.008

摘要：

随着我国经济的快速发展，大量污染物进入农产品产地环境并逐渐超过其容量限制，引发诸多环境问题，污染事件层出不穷，农产品产量下降、质量降低，严重影响我国农业生产和农村经济的可持续发展。南方地区城镇化起步早、发展快，初期经济发展均以牺牲环境为代价，特别是土壤重金属污染问题突出，同时南方地区广泛分布的酸雨污染则强化了问题的严重性。本文以长江沿岸的主要农产品产地为研究对象，系统论述了水、土、气等多种环境要素的质量现状，并基于自然因素与人类活动影响探讨了污染成因，提出环境污染防治策略，对于提升南方农产品产地环境污染治理的科学性，保障农业可持续发展、农产品质量安全、生态环境安全和人民群众健康安全都具有重要意义。

关键词： 南方农产品产地     环境污染     防治策略    

HTML PDF 收藏

标题 作者 时间 类型 操作

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

期刊论文

Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

期刊论文

WHEAT STRIPE RUST AND INTEGRATION OF SUSTAINABLE CONTROL STRATEGIES IN CHINA

期刊论文

HEMIPTERAN-TRANSMITTED PLANT VIRUSES: RESEARCH PROGRESS AND CONTROL STRATEGIES

期刊论文

A review on the forward osmosis applications and fouling control strategies for wastewater treatment

期刊论文

Exploration of Strategies for Chronic Disease Prevention and Control and Relevant System Development

Long-de Wang

期刊论文

Control strategies for disinfection byproducts by ion exchange resin, nanofiltration and their sequential

期刊论文

Design and evaluation of control strategies in urban drainage systems in Kunming city

Xin Dong, Senchen Huang, Siyu Zeng

期刊论文

SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

期刊论文

Integrated control strategies for railway vehicles with independently-driven wheel motors

FENG Jinzhi, LI Jun, Goodall R. M.

期刊论文

Impact of selection of DC base values and DC link control strategies on sequential AC-DC power-flow convergence

Shagufta KHAN,Suman BHOWMICK

期刊论文

Assessment of vaccination strategies against highly pathogenic avian influenza in China

Honglei SUN,Jinhua LIU

期刊论文

High pressure air spray assistant power supply control strategies and their effects on diesel engine

HAN Yongqiang, LIU Zhongchang, WANG Zhongshu, ZHU Ruoqun

期刊论文

interventions combined with CTLA-4 and PD-1/PD-L1 blockade for the treatment of tumors: mechanisms and strategies

期刊论文

南方农产品产地主要环境问题成因与防治策略

黄彩红, 席北斗, 唐朱睿, 袁文超

期刊论文